Basic & Translational Mechanisms of Headache:

  • Human Neurobiology & Neurophysiology
  • Non‑human Neurobiology & Animal Models
  • Neuroinflammation & Immune Mechanisms
  • Genetics & Epigenetics
  • Biomarkers & Endocrine Modulators (e.g., GLP‑1)

Therapeutics for Migraine & Tension‑Type Headache:

  • Pharmacology & Mechanisms of Action
  • Neuromodulation Approaches
  • Early Phase I Clinical Studies
  • Phase II–III Clinical Trials
  • Phase IV / Post‑marketing Studies

Cluster Headache & Trigeminal Autonomic Cephalalgias (TACs):

  • Novel Imaging Findings
  • Pathophysiological Advances
  • Pharmacological & Non‑pharmacological Treatments

Clinical Outcomes, Metrics & Real‑World Evidence:

  • Real‑World Studies & Disease Burden
  • Patient‑Reported Outcomes & Quality of Life
  • Long‑term Outcomes of Preventive Therapies
  • Evaluation of Non‑pharmacological Interventions (e.g., mindfulness, acupuncture)
  • Combination Therapy Assessment
  • Prevention Strategies

Advances in Clinical Headache Care & Implementation:

  • Standardization of Diagnostic Criteria & Tools
  • Routine Integration of Patient‑Reported Outcomes
  • Reducing Diagnostic & Treatment Delays
  • AI Integration in Diagnosis & Treatment
  • Apps, Wearables & Digital Health

Equity & Special Populations:

  • Sex & Gender Differences in Headache Care
  • Pediatric & Adolescent Headache Research
  • Headache Care for Vulnerable Populations
  • Pediatric CGRP‑related Research

Secondary Headaches, Imaging & Acute Management:

  • Secondary Headache Imaging & Pathophysiology (Human)
  • Medication Overuse Headache
  • Updates on Red Flags for Secondary Causes
  • CSF Findings & Headache
  • Emergency Department Management

Comorbidity‑Focused Headache Research:

  • Psychiatric Comorbidities (depression, anxiety, PTSD)
  • Sleep Disorders & Headache
  • Migraine with Cardiovascular Disease
  • Migraine & Obesity
  • Chronic Overlapping Pain Syndromes
  • Environmental & Lifestyle Determinants
  • Planetary Health & Headache
  • Light Exposure, Circadian Disruption & Sleep
  • Urbanization, Sensory Load & Occupational Headaches
  • Nutrition, Dietary Triggers & Caffeine (risks/benefits/dependence)
  • Physical Activity & Exercise Biology
  • Climate Change & Environmental Triggers
  • Air Pollution & Neuroinflammation

Other / Unclassified Research Topics:

For headache research that does not fit the above categories